Recent interests in mixed metal oxide nanostructured materials especially IrxRu1-xO2 compounds have been mainly driven by the technological application as electrocatalyst and electrode materials. We present room temperature Raman scattering results of single crystalline Ir(x)Ru(1-x)O2 (0 <= x <= 1) nanowires grown by atmospheric pressure chemical vapor deposition. We observed that the E-g, the A(1g), and the B-2g phonon modes of a single IrxRu1-xO2 nanowire are blue-shifted linearly with respect to the Ir contents from which we could get stoichiometry information. We also observed that the asymmetric lineshape and the broadening of the full width at half maximum of the E-g mode that involves the out-of-plane oxygen vibration. The unusual asymmetric broadening of the E-g phonon can be explained by the activation of the non-zone-center phonons due to substitutional disorder present in the system. We also found that there is a mixed mode of the A(1g) and the B-2g phonons due to the substitutional disorder, in the range of 630-750 cm(-1). (C) 2013 Elsevier B.V. All rights reserved.