This paper's aim was to model the adsorption of VOC (volatile organic compound) vapor from gas streams onto fixed bed porous adsorbent particles under various operation conditions. A mathematical model based on gas plug flow was developed to predict the process dynamics. An experimental study to highlight the influence of process variables on adsorption dynamics, described by bed saturation curves, was performed in order to identify the more relevant model parameters for the laboratory scale fixed bed adsorption column used. Experimental data concerning the adsorption of n-hexane and 2-propanol from air streams onto fixed bed granular activated carbon emphasized an increase in saturation adsorption capacity of activated carbon at high values of operation temperature and species boiling point as well as at a low level of air superficial velocity. The model predicted well the real conditions, and it could facilitate the design, scale-up, and operation of fixed bed adsorption columns.