Aqueous-phase reforming of polyols was investigated in the current work by mathematical modeling using sorbitol, which represents a C-6-polyol originating from biomass processing. The reaction was studied in the presence of Pt/Al2O3 catalyst at 498 K and 29.3 bar in a continuous fixed-bed reactor under kinetic control. The feasible scheme describing main pathways of sorbitol transformation was proposed considering experimental and literature data. The kinetic model was compared with experimental data through numerical data fitting showing good correspondence.