In this work an image-based multiresolution sensor for online prediction of crystal size distribution (CSD) is proposed. The mean and standard deviation of log-normal probability density function as the CSD can be predicted through the online sensor. In the proposed approach, texture analysis of fractal dimension (FD) and energy signatures as characteristic parameters to follow the crystal growth is utilized. The methodology consists of a combination of thresholding and wavelet-texture algorithms. The thresholding method is used to identify crystal clusters and substrate empty backgrounds. Wavelet-fractal and energy signatures are performed afterward to estimate texture on crystal clusters. Following the texture information extraction, a nonlinear mapping consisting of an artificial neural network (ANN) is incorporated using as inputs the texture information in conjunction with the available online process conditions (flow rate and temperature). A software framework developed in MATLAB enables the configuration of the image acquisition parameters as well as the processing of the online images. Validations against experimental data are presented for the NaCl water ethanol anti-solvent crystallization system.