A novel palladium-based metallacage was self-assembled. This nanocage displayed two complementary effects that operate in synergy for guest encapsulation. Indeed, a metal complex, [Pt(NO2)(4)](2-), was hosted inside the cavity, as demonstrated by solution NMR studies. Single-crystal X-ray diffraction shows that the guest adopts two different orientations, depending on the nature of the host guest interactions involved. A density functional theory computational study is included to rationalize this type of host guest interaction. These studies pave the way to a better comprehension of chemical interaction and transformation within confined nanospaces.