In the present study, a simple and sensitive buspirone hydrochloride (BPH) sensor was developed based on multiwalled carbon nanotubes (MWCNT) modified electrode. The modified electrode was characterized using transmission electron microscopy and electrochemical impedance spectroscopy. The MWCNT modified electrode showed an enhanced oxidation peak current response toward BPH than unmodified electrode. The oxidation peak potential of BPH at modified electrode was 0.85, which was quite lower than that of bare electrode (0.88 V). The BPH was successfully determined at modified electrode using different electrochemical methods, such as cyclic voltammetry (CV), differential pulse voltammetry (DPV), and amperometry. The good sensitivity and linear range response of BPH were obtained using amperometry when compared with other methods employed in this study (CV and DPV). The modified electrode displayed the electro-oxidation of BPH in the linear response from 0.5 to 99.5 mu M with the sensitivity of 16.49 mu A mu M-1 cm(-2). The limit of detection was calculated as 0.22 mu M. In addition, the modified electrode exhibited a good repeatability and repeatability with acceptable stability.