Journal of Bioscience and Bioengineering, Vol.117, No.2, 200-202, 2014
Enhanced production of a self-toxic antibiotic xinghaiamine A from the novel marine-derived species Streptomyces xinghaiensis by resin addition
An addition of 3% (w/v) adsorbent resin HP-20 at 3 days post-inoculation significantly improved xinghaiamine A production from 0.35 to 3.4 mg/L and shortened fermentation time from 18 to 9 days. Self-cytotoxicity of xinghaiamine A was verified and the minimal inhibitor concentration was estimated to be 8 mu g/mL.(C) 2013, The Society for Biotechnology, Japan. All rights reserved.
Keywords:Streptomyces xinghaiensis;Antibiotic production;Resin HP-20;Self-cytotoxic effects;Staphylococcus aureus