The solubilization behavior of paracetamol (PCT) in a diethylene glycol monoethyl ether (Transcutol)-water mixture at (298.15 to 333.15) K is not reported in literature so far. Therefore, attempts were made to investigate the solubilization behavior of PCT in monosolvents and various Transcutol-water mixtures at the temperature range of (298.15 to 333.15) K. The mole fraction solubility of PCT was determined by reported shake flask method. The experimental solubility data of PCT in monosolvents and various Transcutol-water mixtures were found to be correlated well with the modified Apelblat model with the correlation coefficients in the range of 0.996 to 0.999. The solubility of PCT was found to be increased significantly with the increase in temperature and mass fraction of Transcutol. The mole fraction solubility of PCT was found to be highest in pure Transcutol (0.111 at 298.15 K) as compared to water and other cosolvent mixtures. The positive values of enthalpies and entropies indicated that the dissolution of PCT is endothermic. Overall, these results indicated that Transcutol could be used as a physiologically compatible cosolvent to enhance the aqueous solubility of PCT. These preliminary studies could be useful in the formulation development of PCT especially in terms of liquid dosage forms.