2,3,5,6-Tetrachloropyridine (TCP) is an important chemical and intermediate for synthesis of pesticides and pharmaceuticals. The solubility of TCP in supercritical carbon dioxide was measured using a static analytical method at temperatures of 313 K, 323 K, and 333 K and pressures in the range of 10.0 MPa to 24.0 MPa. The result showed that TCP solubility increased with the increase of pressure at isothermal conditions, while it decreased with increasing temperature at isobaric conditions. The experimental data were correlated using four density-based models (Chrastil, Mendez-Santiago and Teja, Bartle, and Kumar and Johnston), respectively. The calculated results show good agreement with the experimental data.