The solubility of 2-hydroxypropane-1,2,3-tricarboxylic acid monohydrate in (water + methanol), (water + ethanol) and (water + propan-2-ol) at temperatures ranging from (278.15 to 303.15) K were determined by a static method. It was found that the solubility of 2-hydroxypropane-1,2,3-tricarboxylic acid monohydrate increases with increasing temperature and decreases with increasing water fraction in (water + methanol), (water + ethanol) and (water + propan-2-ol). The Wilson model and NRTL model were used to correlate the experimental data and the NRTL model gave the best correlation results. The mixing Gibbs free energy was calculated based on the NRTL model. The negative values of mixing Gibbs free energy were obtained and indicated the variation trend of the solubility.