Activity coefficients of the 1-alkyl-3-methylimidazolium bromide [C(n)mim]Br (n = 3 to 8) ionic liquids (ILs) in fructose + water mixed solvents at 298.15 K were determined by cell potential measurements. The molalities of [C(n)mim]Br ranged from (0.005 to 0.1) mol.kg(-1) and those of fructose from (0.2 to 0.8) mol.kg(-1). Gibbs free energy interaction parameters were also obtained together with salt constants. The interactions between [C(n)mim]Br and fructose are mainly controlled by electrostatic interactions. Gibbs free energy interaction parameters (g(ES)) and salting constants (k(S)) are negative for the ILs (n = 3 to 6), indicating fructose are salted-in by the ILs in water, whereas fructose are salted-out by the ILs (n = 7 and 8).