Isobaric vapor-liquid equilibrium (VLE) data for the binary systems of (ethane-1,2-diol + butane-1,4-diol, ethane-1,2-diol + 2-(2-hydroxyethoxy)ethan-1-ol, butane-1,4-diol + 2-(2-hydroxyethoxy)ethan-1-ol, and 2-(2-hydroxyethoxy)ethan-1-ol + 2-[2-(2-hydroxyethoxy)ethoxy]ethanol} have been experimentally measured at 10.0 kPa, 20.0 kPa, and 40.0 kPa using a modified Rose-Williams still in this study. The experimental data of the binary systems were well-correlated by universal quasichemical (UNIQUAC), non-random two-liquid (NRTL), and Wilson activity coefficient models at the three subatmospheric pressures, and the calculated values of the three models agreed well with the experimental data. Then the VLE data of the four binary systems were checked by the Herington area test and Van Ness point test, which showed thermodynamic consistency.