Solvent screening plays a key role in the optimization of the drug crystallization process based on the solubility data and dissolution thermodynamic data. In this article, the solubility of cefixime trihydrate in ethanol, propan-2-ol, butan-1-ol, butan-2-ol, pentan-1-ol, ethyl acetate, and acetone from 278.15 to 323.15 K at atmospheric pressure is reported. It is found that the solubility of cefixime trihydrate in all seven solvents increases with temperature. The modified Apelblat equation fits well with the experimental solubility data in all selected solvents with the average percent deviation less than 3.5 %. The mixing properties including the mixing free Gibbs energy, enthalpy, and entropy of cefixime trihydrate were calculated based on the van't Hoff equation. The results indicate that the dissolution process of cefixime trihydrate in all tested solvents is endothermic, entropically driven and not spontaneous.