A facile method has been developed for the synthesis of core-shell nanostructure poly(N-isopropylacrylamide) grafted on silica nanoparticles (SiO2 NPs) by using the combination of ARGET ATRP and thiol-ene click chemistry. The covalent attachment of the thermoresponsive polymer was achieved by taking advantage of the fast, robust, and high efficient thiol-ene click reaction as demonstrated by FT-IR and XPS. The ARGET ATRP provides the good conversion of the monomer in a well-controlled manner as indicated by the narrow value of PDI (1.21). The grafting amount of the polymer on SiO2 NPs was found to be ca. 18 % as determined by TGA technique. TEM images of the encapsulated SiO2 NPs suggested that the SiO2 NPs core was covered by the soft polymer layer. Interestingly, dynamic light scattering analysis revealed that the as-synthesized nanocomposites exhibited the thermo-responsive behavior with the transition temperature around 31-33 degrees C.