This study presents a novel design methodology for the feasibility and technical evaluation of reactive distillation (RD), and discusses the applicability of various design methods of RD. The proposed framework for the feasibility evaluation determines the boundary conditions (e.g. relative volatilities, target purities, equilibrium conversion and equipment restriction), checks the integrated process constraints, evaluates the feasibility and provides guidelines to any potential RD process application. Providing that a RD process is indeed feasible, a technical evaluation is performed afterward in order to determine the technical feasibility, the process limitations, working regime and requirements for internals as well as the models needed for RD. This approach is based on dimensionless numbers such as Damkohler and Hatta numbers, as well as the kinetic, thermodynamic and mass transfer limits. The proposed framework for feasibility and technical evaluation of reactive distillation allows a quick and easy feasibility analysis for a wide range of chemical processes. In this work, several industrial relevant case studies - e.g. synthesis of di-methyl carbonate (DMC), methyl acetate hydrolysis, toluene hydro-dealkylation (HDA) process, fatty acid methyl esters (FAME) process and unsaturated polyesters synthesis - clearly illustrate the validity of the proposed framework. (C) 2012 Elsevier B.V. All rights reserved.