Comparison of pilot plant partial oxidation of meal rape and hydrocarbon oil mixture with process simulation using equilibrium reactor model by process simulator Aspen Plus resulted in a good agreement. The application of representative compounds method for simulation of such complex mixture was found as a useful tool for optimal process conditions prediction. Based on this procedure the ratio feed to both oxygen and steam were proposed for prediction of good experimental parameters for good process yield of hydrogen. It was stated that key parameter lambda (or analogously oxygen to feed ratio) controlling the partial oxidation process in optimal regime should be in the interval 0.6-0.8, i.e. under reduction conditions. (C) 2011 Elsevier B.V. All rights reserved.