The reaction of benzaldehyde with n-butylamine to form the imine (1-butanamine, N-(phenylmethylene)) was chosen to demonstrate the ability of the mesoscale OBRs to rapidly screen process conditions and obtain kinetic data in both continuous "multi-steady state" and "dynamic screening" manner. The two methods give similar to 98% degree of agreement, with clear step-changes between different residence times. In situ FTIR spectroscopy was used to determine concentrations in real time. The results showed that the average rate constant was 2.0 x 10(-1) +/- 0.006 mol(-0.9) s(-1) with about similar to 1.0% different between the methods. In determining such kinetic information, the meso-OBR was able to reduce the process development time by about 50% of, and required 75% less reagent, compared to batch screening using standard beaker. Furthermore, the data was more reproducible with the average deviation three times lower across all the data points. Crown Copyright (C) 2013 Published by Elsevier B.V. All rights reserved.