This paper presents the calibration of a steady state Rate Based Model (RBM) for distillation based on multiple experiments. A packed column is considered, using non-equilibrium stages to represent the packing segments. For an efficient and accurate calibration, the number of model equations and parameters is first reduced via analytical manipulations and a sensitivity analysis. Second, the model is formulated such that a sparse and banded Jacobian can be exploited. Finally, novel constraints on the physical parameters are derived such that the parameter estimation yields consistent results. The model prediction capabilities are successfully validated with experimental data. (C) 2013 Elsevier Ltd. All rights reserved.