Steady state absorption, emission, and picosecond time resolved fluorescence and transmission electron microscopic (TEM) techniques have been exploited to substantiate and characterize the formation of a substrate anchored beta-cyclodextrin nanotubular suprastructure in aqueous medium. Experimental results reveal that suprastructure is originated from a purely ground state interaction between a newly developed bisindole based drug molecule namely 3,3'-bis(indolyl)-4-chlorophenylmethane (BICPM) with p-cyclodextrin. The bound drug molecule is susceptible to be released out from the supramolecular complex in a controlled manner by the use of endogenous surfactants and is poised to serve a significant purpose in targeted drug delivery preferably at the intestinal region. (C) 2013 Elsevier B.V. All rights reserved.