The steam network of site utility system can produce steam at different levels in process industries and the excess steam can be used to produce the desalinated water simultaneously. In this paper, optimization of coupling site utility to MED-RO desalination has been evaluated. Total site analysis has been applied to better understand the integration between site utility and MED-RO desalination system. Also, estimation of cogeneration potential prior to the design and optimization of the central utility is vital to set targets on site fuel demand as well as heat and power production. So, an accurate targeting model has been used for integration of MED desalination and site utility of process plant. In this regard, the new procedure has been developed based on total site analysis and exergoeconomic optimization to find optimal coupling of site utility and MED-RO desalination system. (C) 2013 Elsevier B.V. All rights reserved.