In this study, thin film nanocomposite (TFN) membrane was developed using novel polysulfone-titanium dioxide (PSf-TiO2) nanocomposite substrate. The effects of TiO2 on the PSf substrate morphologies, hydrophilicity and water permeability were investigated and discussed. The results revealed that the hydrophilicity and the porosity of the substrate were improved upon the TiO2 addition, leading to significant enhancement in water flux. TFN membrane was then fabricated by establishing a polyamide layer made of 1,3-phenylendiamine and 1,3,5-benzenetricarbonyl trichloride monomers over the surface of the modified substrate. Compared with the typical TFC and commercial CTA membranes, the TFN membrane prepared always demonstrated much higher FO water flux without showing a significant increase in reverse solute flux when tested under same conditions. When tested in AL-FS orientation using 0.5M NaCI as a draw solution and 10 mM NaCI as feed solution, the water flux of the TFN membrane was similar to 120% and similar to 87% higher than that of the commercial membrane and typical TFC membrane, respectively. The water flux of the TFN membrane was also reported to be much higher under prolonged filtration time, mainly due to the improved properties of substrate upon addition of TiO2. (C) 2013 Elsevier B.V. All rights reserved.