An electrochemical microtiter plate (eMTP) was developed which enables parallelized electrochemical experiments in combination with simultaneous optical data acquisition and can be employed in a standard microtiter plate reader. The eMTP system was evaluated with the redox probe potassium ferrocyanide. Furthermore in a screening application the decoloration of the dye indigo carmine via electrochemically oxidized ABTS was tested at several reaction conditions. The novel eMTP system is a simple and useful technique for the screening of electrochemical reaction systems by providing optical and electrochemical data simultaneously in up to eight wells in parallel. (C) 2012 Elsevier Ltd. All rights reserved.