A novel nonenzymatic glucose sensor, based on gold nanoparticle-modified indium tin oxide electrode (Au/ITO) with ion implantation technique, is presented in this article. Ion implantation method is simple, low-cost and environmental friendly without using any of other chemicals. Through this method, the ITO substrate can be modified by gold nanoparticles (AuNPs) directly. The fabricated electrode was characterized by atomic force microscopy (AFM), X-ray photoelectron spectroscopy analysis (XPS) and cyclic voltammetry (CV). Electrochemical oxidation of glucose with Au/ITO electrode was examined by CV in alkaline aqueous solution. The modified electrode exhibits good electrochemical behavior towards glucose, providing a wide linear range of 1 similar to 170 mu M and 0.2 similar to 15 mM and a low detection limit with 0.4 mu M. Moreover, this glucose sensor displays acceptable reproducibility and long-term stability. These results indicate that Au/ITO electrode makes it promising for the fabrication of nonenzymatic glucose sensors. (C) 2014 Elsevier Ltd. All rights reserved.