참치 뼈에서 추출한 천연 Hydroxyapatite를 이용한 세라믹 복합체 및 Glass-Ceramics의 특성

최진삼; 이창국; 전유진; 변희국; 김세권

Journal of the Korean Industrial and Engineering Chemistry, Vol.10, No.3, 394-399, May, 1999

Properties of the Ceramic Composites and Glass-Ceramics Prepared by Using the Natural Hydroxyapatite Derived from Tuna Bone

최진삼, 이창국, 전유진, 변희국, 김세권

초록

바이오 세락믹스와 같은 의료용재료의 출발물질에 사용되는 화학시약을 대신하여 참치 뼈로부터 추출한 천연 hydroxyapatite를 이용하여 세라믹 복합체와 glass-ceramics 등을 제조하였다. 복합체의 경우 pseudowollastonite(α-CaSiO₃)와 β-tricalcium phosphate(β-TCP)가 주 결정상으로, 그리고 glass-ceramics 는 pseudowollastonite, β-TCP 및 핵형성제로 포함시킨 CaF₂에 의한 fluoroapatite상이 각각 관찰되었다. 복합체의 미세구조 변화 양상은 열처리 온도의 함수로 결정상의 입자 크기가 증가하는 일반적인 미세조진 구조의 형태를 나타내었고, 900℃로 4시간 동안 대기 상에서 제조한 glassceramics의 강도는 90 MPa로 나타났다.

As the prosthetic application of natural mineral substituted for chemical reagent, composites and a glass-ceramics containing hydroxyapatite isolated from tuna bone were prepared by solid state reaction. On x-ray examinations, the major phases of composites were identified as pseudowollastonite(α-CaSiO₃) and β-tricalcium phosphate(β-TCP) and the phase of a glass-ceramics was observed as β-TCP and fluoroapatite caused by CaF₂, respectively. SEM images depict that the microstructures of grain at the composites were a function of temperature. The measured strength of a glass-ceramics prepared at 900℃ for 4 hr in air was 90 MPa as a 4-point bending method and this value was similar to the cortical bone, as 50∼150 MPa but it was lower than its maximum strength.

Keywords:Glass-ceramics;Pseudowollastonite;β-Tricalcium Phosphate;Fluoroapatite;Tuna Bone

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[1] Hench LL, Wilson J, "An Introduction to Bioceramics," in Advanced Series in Ceramics, ed L.L. Hench and J. Wilson, p. 15 World Scientific (1993)

[2] Pernot F, Zarzycki J, Bonnel F, Rabischong P, Baldet P, J. Mater. Sci., 14, 1694 (1979)

[3] Mer H, Deutscher K, Blencke B, Pfeil E, Strung V, Sci. Ceram., 9, 219 (1977)

[4] Sivakumar M, Sampath Kumar TS, Shantha KL, Panduranga Rao K, Biomaterials, 17, 1709 (1996)

[5] 安江任, 遠山岳史, 井康夫, Inorg. Mater., 3, 475 (1996)

[6] 高野直久, "天然アパタイト(HAB-B): 魚骨からのバイオセラミクスについて," マリンバイオ海洋バイオ新素材·新物質," 監修松永是. ツ－エムツ－p. 214 (1989)

[7] 이창국, 최진삼, 전유진, 변희국, 김세권, 한국수산학회지, 30, 652 (1997)

[8] 김세권, 이창국, 전유진, 변희국, 이응호, 최진삼, 한국공업화학학회지, 8, 994 (1997)

[9] 김세권, 최진삼, 이창국, 변희국, 전유진, 이응호, 한국공업화학학회지, 8, 1000 (1997)

[10] 김세권, 최진삼, 이창국, 변희국, 전유진, 이응호, 박인용, 한국공업화학학회지, 8, 322 (1998)

[11] Kokubo T, Ito S, Shigenmatsu M, Yamamura T, J. Mater. Sci., 20, 2001 (1985)

[12] Ito S, Sakka S, J. Mater. Sci., 21, 536 (1986)

[13] Kokubo T, J. Ceram. Soc. Jpn., 95, 786 (1987)

[14] Audekercke RV, Martens M, "Mechanical Properties of Cancellous Bone, in Natural and Living Biomaterials," Eds., G.W. Hastings and P. Ducheyne, CRC Press, Boca Raton, FL, 89 (1984)

[15] Kempson E, Annals Rheumatic Diseases, 41, 508 (1982)

[16] Kingery WD, Bowen HK, Uhlman DR, "Introduction to Ceramics," John Wiley & Sons, Inc., 481 (1960)

[17] Clifford A, Hill R, J. Non-Cryst. Solids, 196, 346 (1996)