This paper presents the effect of operating water mist system to enhance the energy efficiency of air-cooled chillers under various operating conditions. A thermodynamic model for an air-cooled chiller with twin refrigeration circuits coupled with a water mist system was developed and validated by measured operating data. The validated model was used to investigate how the thermal properties of the entering condenser air and the performance of the air-cooled chiller varied under different operating schemes with water mist pre-cooling. Under the conventional head pressure control (HPC) with a designed water mist generation rate, the coefficient of performance (COP) increased by up to 21.3%. The chiller performance could be improved further under variable condensing temperature control (CC). Under CTC, chiller COP was increased up to 51.5% with optimal water mist generation rate. The potential energy savings of these chillers serving a representative office building in subtropical climate was evaluated, and CTC coupling with optimal water mistgeneration rate would reduce the annual total electricity consumption for cooling by 14.1%. The water consumption of the water mist system was comparatively small, comparing with the total water losses for an open-loop cooling tower system with equivalent heat rejection capacity. (C) 2012 Elsevier B.V. All rights reserved.