Although there have been multiple studies on window thermal properties in energy-efficient fenestration design, the effects of building geometry factors have been studied much less. The study presented in this paper evaluated the role of geometry factors, such as window orientation, window to wall ratio, and room width to depth ratio, on building energy performance in a commercial office building. A series of energy simulations were performed for six climate zones in the United States using a model of a room in a typical office building created in Design Builder, an energy analysis program, to evaluate total annual energy consumption. The simulation results were analyzed to find the combination of parameters yielding the lowest energy consumption and to define potential energy savings for office buildings located in various climate zones. The study showed that geometry factors affect energy consumption significantly in hot climates (Zones 2 and 3) and cold climates (Zones 6 and 7) but only marginally in temperate climates (Zones 4 and 5). Energy savings were on average 3% and 6% reaching a maximum of 10% and 14% in hot climates (Zones 2 and 3) and 1% in temperate and cold climates (Zones 4-7). (c) 2012 Elsevier B.V. All rights reserved.