Energy consumption of buildings depends significantly on the criteria used for the indoor environment and building design and operation. The environmental factors that define the indoor environmental quality are: thermal comfort, indoor air quality, acoustic comfort and visual comfort. This paper approaches the numerical prediction of thermal comfort in closed spaces on the basis of PMV-PPD model, and its testing to asymmetric or nonuniform thermal radiation, as well as the indoor air quality simulation and control. The following are developed: a computation and testing model of thermal comfort in buildings, a computational model for indoor air quality numerical simulation, as well as a methodology to determine the outside airflow rate and to verify the indoor air quality in rooms, according to the European Standard CEN 1752. Also, the thermal comfort criteria for design of heating systems, the relationship between thermal environment and human performance, as well as the influence of carbon dioxide on human performance and productivity are presented. The performance of the developed computational models, implemented in two computer programs, is illustrated by using some numerical comparative applications for two building construction types. (C) 2013 Elsevier B.V. All rights reserved.