MYRRHA (Multi-purpose hYbrid Research Reactor for High-tech Applications) is the flexible experimental Accelerator-Driven System (ADS) currently under development at SCK.CEN and will replace the Material Testing Reactor (MTR) BR2. The MYRRHA facility is currently being developed with the aid of the FP7-project "Central Design Team" and will be as a flexible irradiation facility, able to work in both subcritical and critical modes. In this way, MYRRHA will allow fuel developments for innovative reactor systems, material developments for GEN IV systems, material developments for fusion reactors, radioisotope production for medical and industrial applications, and Si-doping. MYRRHA will also demonstrate the full concept of Accelerator Driven Systems by coupling the requisite three components (accelerator, spallation target and subcritical reactor) at reasonable power level to allow operation feedback, scalable to an industrial demonstrator and allow for the study of efficient transmutation of high-level nuclear waste. Since MYRRHA is based on the heavy liquid metal technology, Lead-Bismuth Eutectic, it will be able to significantly contribute to the development of Lead Fast Reactor (LFR) technology. Further, in critical mode, MYRRHA will play the role of European Technology Pilot Plant in the path forward for LFR. In this paper we present the historical perspectives, international and high profile membership within the consortium of the MYRRHA project and the rationale for the design choices are presented. Also, the latest configuration of the reactor system is described together with the different irradiation capabilities. More specifically, the possibilities and performances for fuel irradiations are presented in detail. (C) 2012 Elsevier Ltd. All rights reserved.