The solubility of florfenicol in mixed 1,2-propanediol + water solvents was measured by a static analytical method at the temperature ranging from 293.15 K to 316.25 K. The experimental solubility data was correlated by the modified Apelblat equation, the General Single model and the Hybrid model. The results show that: the mole solubility of florfenicol in binary 1,2-propanediol + water mixtures increased with increasing temperature and the mole fraction of 1,2-propanediol in the binary solvent system; the values of the solubility calculated by the three models show good agreement with the experimental value; the OMPD from the modified Apelblat equation, the General Single model and the Hybrid model are 2.48, 2.07 and 5.12, respectively. However, compared to the modified Apelblat equation and the Hybrid model, the General Single model can give more accuracy and reliability of the solubility data. In addition, the discussion of the enthalpy and the entropy for florfenicol in different cosolvents indicated that the dissolution process of florfenicol was endothermic and entropy-driven. Crown Copyright (C) 2013 Published by Elsevier B.V. All rights reserved.