The solubility of 2,3,4,5-tetrabromothiophene in a (ethanol + trichloromethane) binary solvent mixture was measured in the temperature ranging from 278.15 K to 322.15 K. The results obtained from these measurements were fitted using the two variants of the combined nearly ideal binary solvent/Redlich-Kister (CNIBS/R-K) equation and the Jouyban-Acree equation, respectively. All the three equations were proven to give good representations of the experimental data. Computational results showed that the variant 2 of CNIBS/R-K equation was superior to the other two equations. In addition, the thermodynamic properties of the solution process, including the Gibbs energy, enthalpy, and entropy were calculated by the van't Hoff analysis. The experimental results showed that ethanol could be used as effective anti-solvents in the crystallization process. (C) 2013 Elsevier B.V. All rights reserved.