In the current study, hot melt pressure sensitive adhesives (HMPSA) were prepared by blending polystyrene-hydrogenated (3,4-polyisoprene and 1,4-polyisoprene)-polystyrene (HYBRAR7311), polymethyl methacrylate-polybutyl acrylate-polymethyl methacrylate (LA2250), tackifier, and other additives in an internal mixer. The compatibility of LA2250, HYBRAR7311, and glycerol rosin ester was investigated on the basis of transparency, differential scanning calorimeter, and scanning electron microscope. The results indicated that glycerol rosin ester was compatible with HYBRAR7311 and LA2250, while HYBRAR7311 was only partly compatible with LA2250. Besides, styrene-ethylene-butene-styrene block copolymers grafted MALEIC ANLYDRIDE was used as compatibilizer added into HMPSA. Although it increased the compatibility and shear strength yet the tack and peel strength were sharply decreased. Simple variable method was used to study the effect of main components on the tack, peel strength, and shear strength of HMPSA. The relationship between adhesive properties and viscoelastic properties of HMPSA was studied via dynamic mechanical analysis. The investigation showed that the smaller storage modulus at low frequency (0.01-0.11/s), the larger the tack. Peel strength was found proportional to G(f(1))/G(f(2))(f(1)=32.031/s, f(2)=0.071/s). Similarly, the effect of this blend on damping performance and substrate on peel strength of HMPSA was investigated which was found excellent in this case. The peel strength of polypropylene was larger when HYBRAR7311 content was more than LA2250. However, the peel strength of polycarbonate and polyethylene glycol terephthalate was larger when LA2250 content was more than HYBRAR7311. Furthermore, the mechanical properties of HYBRAR7311/LA2250 HMPSA were found to be superior to the one-polymer HMPSA.