To obtain experimental data in short time on the degradation of adhesives exposed to moisture, a valuable technique is represented using the open-face configuration. With this technique, a layer of adhesive is first applied on one adherend and exposed to the humid environment; then, the second adherend is bonded and the joint can now undergo mechanical testing. Apart from the acceleration of moisture uptake which is obtained due to the larger area exposed, a further advantage is the uniformity of degradation. A further acceleration can be obtained by adding a hygroscopic contaminant at the adhesive/adherend interface, which speeds up moisture uptake and accentuates the interfacial nature of the failure. The main aim of this work was to evaluate the decay of the mechanical strength in the absence or presence of a contaminating agent. The specimens studied were single lap joints, tested under static shear loading. Two sets of specimens were considered; in the first set, the adhesive was applied in standard way and in the second set, the adhesive/adherend interface was contaminated with droplets of CaCl2 aqueous solution. Both sets were subjected to humid and warm environment (100% relative humidity, 50 degrees C). After the desired exposure times in the range 1-5 weeks, groups of specimens were dried and bonding of the second adherend was carried out. Then, mechanical testing was performed; the fractured surfaces were examined by scanning electron microscopy. The results show that before degradation the failure type is cohesive, but it changes to interfacial failure as the degradation proceeds. Uncontaminated specimens exhibit gradual degradation during the exposure time; contaminated specimens achieve almost half of the degradation in less than one week; after that, the process continues at lower speed and at the end of the observed period both methods show similar values of failure loads. Additional tests were carried out to assess the moisture absorption in the adhesive layer and relate it to the exposure time.