The present study is our attempt to develop a first robust protocol for one-pot transformation of vegetable oils, such as soybean oil, to a mixture of FAMEs and glycerol ether derivatives as final potential biofuel. The reaction is catalyzed by amorphous silica oxide functionalized with 10 wt% of sulfonic groups. The best performance was observed when a mixture of substrate/tert-butyl-methyl ether in 1: 10 ratio and almost 1% catalyst was treated under microwave conditions fixed at 20 W. (C) 2013 Elsevier Ltd. All rights reserved.