This paper presents a new in-cylinder mixture preparation and ignition system for various fuels including hydrogen, methane and propane. The system comprises a centrally located direct injection (DI) injector and a jet ignition (JI) device for combustion of the main chamber (MC) mixture. The fuel is injected in the MC with a new generation, fast actuating, high pressure, high flow rate DI injector capable of injection shaping and multiple events. This injector produces a bulk, lean stratified mixture. The JI system uses a second DI injector to inject a small amount of fuel in a small pre-chamber (PC). In the spark ignition (SI) version, a spark plug then ignites a slightly rich mixture. in the auto ignition version, a DI injector injects a small amount of higher pressure fuel in the small PC having a hot glow plug (GP) surface, and the fuel auto ignites in the hot air or when in contact with the hot surface. Either way the MC mixture is then bulk ignited through multiple jets of hot reacting gases. Bulk ignition of the lean, jet controlled, stratified MC mixture resulting from coupling DI with JI makes it possible to burn MC mixtures with fuel to air equivalence ratios reducing almost to zero for a throttle-less control of load diesel-like and high efficiencies over almost the full range of loads. (C) 2009 Professor T. Nejat Veziroglu. Published by Elsevier Ltd. All rights reserved.