Proton-exchange membrane (PEM) electrolyzers have been a source of interest due to the ability of these electrolyzers to produce product gases at high differential pressures across the membrane electrode assembly (MEA) without the need for external compression. This work studies species transport within the membrane of a high-pressure oxygen-generating water electrolyzer using the dusty-fluid model (DFM) for the case involving liquid water being supplied to the cathode. The model was calibrated against experimental polarization data from Hamilton Sundstrand's high-pressure oxygen generating assembly (HPOGA) at varying differential oxygen pressures. The governing equations were cast in a non-dimensional form to examine the dehydration of the cell with increasing current density and differential pressure expressed in terms of a Damkohler number and the ratio of the membrane diffusion coefficient to the species diffusion coefficient. It was determined that the dehydration of the cell occurred at an approximately constant Damkohler number of 0.196 +/- 0.004 regardless of the ratio of the pressure difference. It was also observed that electro-osmotic drag had a strong influence on the dehydration of the cell since the drag coefficient directly and substantially elevated the required water flux for a given current density operation above what was needed based only on the stoichiometry of the chemical reactions. Copyright (C) 2012, Hydrogen Energy Publications, LLC. Published by Elsevier Ltd. All rights reserved.