IrxRu1-xO2(1 >= x >= 0) with nanorod structure were successfully synthesized by employed pre-filling the Ir and/or Ru guest species into the peripheral-pore of NH2-modified as-synthesized SBA-15 and explored as electrocatalyst for oxygen evolution reaction (OER) in water electrolyzers. Various physicochemical parameters for zeolite template and/or IrxRu1-xO2 were obtained by SEM, TEM, XRD, EDX and N-2 gas absorption/desorption measurements. The morphology for prepared IrxRu1-xO2 samples with individual and/or cluster nanorods was changed with the component difference. Cyclic voltammetry, linear sweep voltammetry, electrochemical impedance spectroscopy, steady state polarization curves and stability tests were performed to investigate the catalytic activity and stability of these electrocatalysts for OER. The cell with catalyst RuO2 showed best catalytic performance with the lowest onset potential (1.374 V at 10 mA cm(-2)), which may be ascribed to regular nanoclusters and larger outer active surface area. Meanwhile, the cell stability tests suggested that the addition of IrO2 in IrxRu1-xO2 improved the stability of the RuO2 catalyst. Copyright (c) 2012, Hydrogen Energy Publications, LLC. Published by Elsevier Ltd. All rights reserved.