We demonstrate that Pd43Ni10Cu27P20 bulk metallic glass (BMG) nanowires, prepared by a facile, scalable top-down nanomolding approach, can be used as high surface area electrocatalysts for alkaline alcohol fuel cell applications. These nanowires exhibit higher activity for methanol and ethanol oxidation in alkaline media compared to pure Pd, quantified by cyclic voltammetry. Furthermore, the Pd-BMG nanowire electrocatalyst has a 300 mV lower onset potential for CO oxidation suggesting improved poisoning resistance beyond pure Pd. The Pd-BMG electrocatalyst activation energies for methanol and ethanol oxidation of 22 and 17 kJ mol(-1) are lower than the pure Pd values of 38 and 30 kJ mol(-1), respectively. Unique properties of BMGs (homogeneity, viscosity, surface tension) facilitate the formability into high surface area electrocatalysts at low processing temperatures. The high electrical conductivity and chemical/physical stability suggest that these materials are ideal candidates for widespread commercial use including energy conversion/storage, hydrogen production, and sensors. Copyright (C) 2013, Hydrogen Energy Publications, LLC. Published by Elsevier Ltd. All rights reserved.