PEMFCs are considered to be clean and efficient electrochemical energy sources. Nevertheless, the commercialization of PEMFCs needs to tackle the high cost of the catalyst layers that contain platinum-based electrocatalysts. The reduction of the platinum content is therefore one of the challenging goals to achieve within fuel cells technologies. The amorphous bi-metallic electro-catalysts studied in this work were Ni(59)Nb(40)pt(0.6)X(0.4) (X = Pd, Rh, Ru, Co) and they were produced by Mechanical Alloying (MA) and used as anodes onto Nafion XL (DuPont (TM)) perfluorinated membranes. A commercial Pt/C catalyst was used on the cathode side. The operating conditions have been 100% relative humidity (RH) and gas and cell temperatures of 25 degrees C, 40 degrees C, 60 degrees C and 80 degrees C. Experiments were carried out on a single PEM fuel cell with an active area of 25 cm(2). These electro-catalysts were characterized by both physical and chemical techniques, such as Differential Scanning Calorimetry (DSC), X-ray Diffraction (XRD) and Energy Dispersive X-ray Spectroscopy (EDX). The results showed that at 80 degrees C, the anode amorphous electrocatalyst based on Ni59Nb40Pt0.6Pd0.4 is the one that provides the best performance in terms of power and current. Copyright (C) 2014, Hydrogen Energy Publications, LLC. Published by Elsevier Ltd. All rights reserved.