An efficient synthesis of core-shell-shell Ag-Pt-Ag nanocubes using Ag nanocubes as reactants was developed. Ag nanocubes were synthesized as seeds; after (NH3)(2)Pt(NO2)(2) was added in situ, the nanocubes underwent epitaxial growth followed by further Ag deposition to form core-shell-shell Ag-Pt-Ag nanocubes. In this study, the successful determination of the core-shell-shell structures of the Ag-Pt-Ag nanocubes by an electrochemical dissolution process was studied. The Ag dissolution was followed by an electrochemical quartz crystal microbalance technique, and hollow Ag-Pt nanocubes were obtained after the third cycle of a cyclic voltammetric method in 0.5 M H2SO4 electrolyte. Additionally, these Ag-Pt-Ag and Ag-Pt nanocubes were used as electrocatalysts in the alkaline oxygen reduction reaction (ORR). Electrochemical measurements were performed using an ultrathin-film rotating ring-disk electrode (RRDE). The mass activities at -0.1 V (vs. Ag/AgCl; within the kinetic control region) in terms of the currents normalized to the Pt mass for the Ag-Pt-Ag and the Ag-Pt nanocubes were 1.08 x 10(-3) and 3.3 x 10(-3) mA mu g(-1) respectively. The data supported by RRDE showed approaching 4 electrons and lower HO2- production over Ag-Pt-Ag nanocubes and Ag-Pt nanocubes, implying that the four-electron pathway governed the ORRs for these two catalysts. After 1000 cyclic tests, Ag-Pt-Ag nanocubes with solid interior displayed superior stability in ORR than hollow Ag-Pt nanocubes. Copyright (C) 2014, Hydrogen Energy Publications, LLC. Published by Elsevier Ltd. All rights reserved