The current study addresses engine specification and second thermodynamic law analysis of the CI diesel engine fueled with hydrogen, DME, and diesel at six engine speeds. The 3-D simulation was first carried out and then the results were exploited to calculate availability through a developed in-house code. Availability analysis was performed separately for chemical and thermo-mechanical availability to highlight each fuel'0s capacity in chemical and mechanical efficiency delivery. The results indicate that hydrogen fuel prevails in chemical and thermo-mechanical availability, indicated power, and mean effective in-cylinder pressure under all crank angle and engine speeds. Temperature distribution has more extensive and intensified region developed across the cylinder, although hydrogen demonstrated the lowest ISFC (indicated specific fuel consumption) value. With regard to engine speed, 2000 rpm shows overall better IP (indicated power), IMEP (indicated mean effective pressure), chemical and thermo-mechanical availability, irrespective of fuel type. The mean irreversibility rate for PMC (pre-mixed combustion) and MCC (mixing controlled combustion) combustion phase shows a different trend. Furthermore, hydrogen fueled engine demonstrates the highest temperature distribution of 2736 K and the wall heat flux to the amount of 29160 W. The variance of chemical availability for Hydrogen from 1500 to 4000 rpm decreases by crank-angle evolution from 43.3% to 10.1% corresponding to 10-40 degrees CA after top dead center. Copyright (C) 2014, Hydrogen Energy Publications, LLC. Published by Elsevier Ltd. All rights reserved.