Leaching column experiments of caliche were performed using seawater as the leaching agent because the caliche deposits are located in Northern Chile where water resources are scarce. The use of seawater without desalination is an attractive alternative for mining operations. The experimental recoveries of different ions were modeled using a hybrid model, which uses empirical information and fundamental principles. The following ions were considered: nitrate, iodine, sulfate, chloride, sodium, potassium and magnesium. The model explicitly considers different column heights, irrigation rates, and leaching agents. A sensitivity analysis showed that parameters associated with the particle level predominantly determined the calculated recoveries. The predictive capability was also tested, and the results were generally good, except for the sulfate ion, the dissolution of which was controlled by the presence of other ions. (C) 2013 Elsevier B.V. All rights reserved.