Thermo-sensitive Interpenetrating Polymer Networks Composed of Poly(N-vinyl pyrrolidone-co-butyl methacrylate) and Poly(acrylic acid)

Jung JH; Sung YK; Cho CS; Lee YM

Korea Polymer Journal, Vol.2, No.1, 27-31, April, 1994

Jung JH, Sung YK, Cho CS, Lee YM

The swelling behavior of interpenetrating polymer networks (IPNs) composed of poly(N-vinyl pyrrolidone-co-butyl methacrylate)[p(NVP-co-BMA)] and poly(acrylic acid) (PAAc) in water was studied and compared with crosslinked p(NVP-co-Aac-co-BMA). The IPNs were synthesized by a sequential IPN method in which crosslinked PAAc chains were formed inside of p(NVP-co-BMA) networks as initial gels. Positive swelling changes were observed with temperature changes for IPNs gels containing higher BMA content while negative swelling changes were observed for random gels. The positive temperature dependence is regarded as the formation and dissociation of hydrogen-bond complexes between NVP and AAc with temperature changes in IPNs gels. The difference in temperature dependence of swelling between IPNs and random gels was attributed to the structural differences of the polymer.

[References]

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Hoffman AS, Afrassiabi A, Dong LC, J. Control. Release, 4, 213 (1986)
Schild HG, Proc. Polym. Sci., Pergamon Press Ltd., 14, p. 163 (1992)
Bae YH, Okano T, Sakurai Y, Kim SW, Pharm. Res., 8, 624 (1991)
Taylor LD, Cerankowsk LD, J. Polym. Sci., 13, 2551 (1975)
Feil H, Bae YH, Feijen J, Kim SW, Macromolecules, 26, 2496 (1993)
Cowie JMG, Swinyard B, Polym. Int., 25, 109 (1991)
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Silberberg A, Eliassaf J, Katchalsky A, J. Polym. Sci., 23, 259 (1957)
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Ohno H, Abe K, Tsuchida E, Makromol. Chem., 179, 755 (1978)
Antipina AD, Buranovskii VY, Papisov IM, Kabanov VA, Vysokomol. Soedin, A13, 348 (1971)
Sasase H, Aoki T, Katono H, Sanui K, Ogata N, Makromol. Chem. Rapid Commun., 13, 577 (1992)

[Referenced By]

[1] Okano T, Bae YH, Jacobs H, Kim SW, J. Control. Release, 11, 244 (1990)

[2] Hoffman AS, Afrassiabi A, Dong LC, J. Control. Release, 4, 213 (1986)

[3] Schild HG, Proc. Polym. Sci., Pergamon Press Ltd., 14, p. 163 (1992)

[4] Bae YH, Okano T, Sakurai Y, Kim SW, Pharm. Res., 8, 624 (1991)

[5] Taylor LD, Cerankowsk LD, J. Polym. Sci., 13, 2551 (1975)

[6] Feil H, Bae YH, Feijen J, Kim SW, Macromolecules, 26, 2496 (1993)

[7] Cowie JMG, Swinyard B, Polym. Int., 25, 109 (1991)

[8] Katono H, Maruyama A, Sanui K, Ogata N, Okano T, Sakurai Y, AAPG Bull., 16, 215 (1991)

[9] Al-Alaw S, Saeed NA, Macromolecules, 23, 477 (1990)

[10] Al-Alaw S, Macromolecules, 24, 4206 (1991)

[11] Silberberg A, Eliassaf J, Katchalsky A, J. Polym. Sci., 23, 259 (1957)

[12] Breitenbach JW, J. Polym. Sci., 23, 949 (1957)

[13] Ohno H, Abe K, Tsuchida E, Makromol. Chem., 179, 755 (1978)

[14] Antipina AD, Buranovskii VY, Papisov IM, Kabanov VA, Vysokomol. Soedin, A13, 348 (1971)

[15] Sasase H, Aoki T, Katono H, Sanui K, Ogata N, Makromol. Chem. Rapid Commun., 13, 577 (1992)