Based on the lattice Boltzmann (LB) approach, a novel hybrid method has been proposed for getting insight into the microscale characteristics of the multicomponent flow of nanofluid. In this method, the whole computational domain is divided into two regions in which different-sized meshes are involved for simulation (fine mesh and coarse mesh). The multicomponent LB method is adopted in the fine mesh region, and the single-component LB approach is applied to the coarse mesh region where the nanofluid is treated as a mixed single-component fluid. The conservation principles of mass, momentum and energy are used to derive a hybrid scheme across the different scaled regions. Numerical simulation is carried out for the Couette flow and convective heat transfer in a parallel plate channel to validate the hybrid method. The computational results indicate that by means of the present method, not only the microscopic characteristics of the nanofluid flow can be simulated, but also the computational efficiency can be remarkably improved compared with the pure multicomponent LB method. (C) 2010 Elsevier Ltd. All rights reserved.