Bioerodible Hydrogel Based on Interpenetrating Polymer Networks Composed of Poly(D,L-lactic acid) and Poly(ethylene glycol) Macromer

Cho CS; Ha SH; Kim SH; Jung YJ; Jo BW; Kwon JK

Korea Polymer Journal, Vol.2, No.2, 91-95, October, 1994

Cho CS, Ha SH, Kim SH, Jung YJ, Jo BW, Kwon JK

Poly(ethylene glycol) (PEG) macromers terminated with acrylate groups and semi-interpenetrating polymer networks (IPNs) composed of poly(D,L-lactic acid)(PLA) and PEG macromer were synthesized and characterized with the aim of obtaining a bioerokeble hydrogel that could be used to release drugs. Polymerization of PEG macromer resulted in the formation of cross-linked gels due to the multifunctionality of macromer. Glass transition temperature (T_g) and melting temperature (T_m) of PEG network and PLA in the IPNs were shifted, indicating an interpenetration of PLA and PEG chains. It was found that water content decreased with increasing PLA weight fraction due to the hydrophobicity of PLA. These IPNs gels degrade upon hydrolysis and their degradation rates can be controled by cross-linking density and the nature of PEG and the mole fraction of PEG in the IPNs.

[References]

Langer R, Science, 249, 1527 (1990)
Heller J, Bioerodible Systems, in: "Medical Applications of Controlled Release," edited by R.S. Langer and D.L. Wise, vol. 1, 70, CRC Press, Boca Raton (1984)
Kulkarni RK, Pani KC, Neuman C, Leonard F, ARch. Surg., 93, 839 (1966)
Domb AJ, Gallardo CF, Langer R, Macromolecules, 22, 3200 (1989)
Heller J, Sparer RV, Zentner GM, "Biodegradable Polymers as Drug Delivery Systems," edited by M. Chaisin, R. Langer, 171, Dekker, New York (1991)
Negishi N, Bennett DB, Cho CS, Jeong SY, vanHeeswijk WA, Feijen J, Kim SW, Pharm. Res., 4, 305 (1987)
Couvreur P, Puisieux F, Adv. Drug Delivery Rev., 10, 142 (1993)
Casey DJ, Jarrett PK, Rosati L, U.S. Patent, 4,716,203 (1987)
Churchill JR, Hutchinson FG, U.S. Patent, 4,526,938 (1985)
Sawhney AS, Pathak CP, Hubbell JA, Macromolecules, 26, 581 (1993)
Sperling LH, "Interpenetrating Polymer Networks and Related Materials," Plenum Press, New York (1981)
Deng XM, Xiong CD, Cheng LM, Xu RP, J. Polym. Sci. C: Polym. Lett., 28, 411 (1990)
Pavia DL, Lampmam GM, Kriz GS, "Introduction to Spectroscopy," W.B. Saunders Co., Philadelphia (1979)
Andini S, Ferrara L, Maglio G, Palumbo R, Makromol. Chem. Rapid Commun., 9, 119 (1988)
Olabisi O, Robeson LM, Shaw MT, "Polymer-Polymer Miscibility," Chapter 3, Academic Press, New York (1979)
Yoshikawa M, Shiota A, Sanui K, Ogata N, New Polym. Mater., 1, 223 (1989)
Pitt CG, Gratzei MM, Kimmei GL, Surles J, Schindler A, Biomaterials, 2, 215 (1981)

[1] Langer R, Science, 249, 1527 (1990)

[2] Heller J, Bioerodible Systems, in: "Medical Applications of Controlled Release," edited by R.S. Langer and D.L. Wise, vol. 1, 70, CRC Press, Boca Raton (1984)

[3] Kulkarni RK, Pani KC, Neuman C, Leonard F, ARch. Surg., 93, 839 (1966)

[4] Domb AJ, Gallardo CF, Langer R, Macromolecules, 22, 3200 (1989)

[5] Heller J, Sparer RV, Zentner GM, "Biodegradable Polymers as Drug Delivery Systems," edited by M. Chaisin, R. Langer, 171, Dekker, New York (1991)

[6] Negishi N, Bennett DB, Cho CS, Jeong SY, vanHeeswijk WA, Feijen J, Kim SW, Pharm. Res., 4, 305 (1987)

[7] Couvreur P, Puisieux F, Adv. Drug Delivery Rev., 10, 142 (1993)

[8] Casey DJ, Jarrett PK, Rosati L, U.S. Patent, 4,716,203 (1987)

[9] Churchill JR, Hutchinson FG, U.S. Patent, 4,526,938 (1985)

[10] Sawhney AS, Pathak CP, Hubbell JA, Macromolecules, 26, 581 (1993)

[11] Sperling LH, "Interpenetrating Polymer Networks and Related Materials," Plenum Press, New York (1981)

[12] Deng XM, Xiong CD, Cheng LM, Xu RP, J. Polym. Sci. C: Polym. Lett., 28, 411 (1990)

[13] Pavia DL, Lampmam GM, Kriz GS, "Introduction to Spectroscopy," W.B. Saunders Co., Philadelphia (1979)

[14] Andini S, Ferrara L, Maglio G, Palumbo R, Makromol. Chem. Rapid Commun., 9, 119 (1988)

[15] Olabisi O, Robeson LM, Shaw MT, "Polymer-Polymer Miscibility," Chapter 3, Academic Press, New York (1979)

[16] Yoshikawa M, Shiota A, Sanui K, Ogata N, New Polym. Mater., 1, 223 (1989)

[17] Pitt CG, Gratzei MM, Kimmei GL, Surles J, Schindler A, Biomaterials, 2, 215 (1981)