The densities (rho) and speeds of sound (u) of betaine hydrochloride (B.HCl) drug (0.01 to 0.06) mol . kg (1) in (0.10, 0.20 and 0.30) mol . kg (1) aqueous D(+)-glucose and sucrose solutions are reported as a function of temperature at T = (293.15 to 313.15) K and atmospheric pressure. The values of density (rho) and speed of sound (u) are obtained with high precision. These values have been used to estimate the apparent molar volume (V-2,V-phi), partial molar volume (V-2(infinity)), transfer partial molar volume (Delta V-t(2)infinity), apparent molar isentropic compressibility (K-s,K-2,K-phi), partial molar isentropic compressibility (K-s,2(infinity)), transfer partial molar compressibility (Delta K-t(s,2)infinity), hydration number (N-H), partial molar expansion (E-2(infinity)) and Hepler's constant (partial derivative V-2(2)infinity/partial derivative T-2)(P). Furthermore, pair (V-AB and K-AB) and triplet (V-ABB and K-ABB) interaction coefficients have been computed from the values of Delta V-t(2)infinity and Delta K-t(s,2)infinity. The co-sphere overlap model is used to understand the values of Delta V-t(2)infinity and Delta K-t(s,2)infinity. The positive values of (partial derivative V-2(2)infinity/partial derivative T-2)(P) indicate structure making ability of betaine hydrochloride in aqueous D(+)-glucose and sucrose solutions at the temperatures and compositions investigated. (C) 2014 Elsevier Ltd. All rights reserved.