Inactivation kinetics (D and z values) of Salmonella typhimurium under high pressure carbon dioxide (HPCD) from 1.51 to 7.56 MPa at 35 degreesC was investigated in model solutions of brain heart infusion broth (BHIB) and physiological saline (PS). The come-up time to reach a pressure exerts an important effect on the survival of S. typhimurium. The inactivation rates increased with pressure, suspending medium and exposure time. Inactivation followed first order reaction kinetics, with specific inactivation rates (k) and decimal reduction times (D) that varied from 0.0975 to 1.5561 min(-1) and from 23.63 to 1.48 min, respectively. The pressure dependence of the S. typhimurium specific inactivation rates can be described by the z(p) value depending on the model solutions BHIB and PS.