This work investigated the removal of metals from wastewater using a combined Membrane Bioreactor-Reverse Osmosis (MBR-RO) system. The concentrate produced by the RO system was treated by a fixed bed column packed with zeolite. The average metal removal accomplished by the MBR treating municipal wastewater was Cu(90%), Fe(85%), Mn(82%), Cr(80%), Zn(75%), Pb(73%), Ni(67%), Mg(61%), Ca(57%), Na(30%) and K(21%), with trivalent and divalent metals being more effectively removed than monovalent ones. The metal removal achieved by the MBR system treating wastewater spiked with Cu, Pb, Ni and Zn (4-12 mg L-1 of each metal) was Pb(96%)>Cu(85%)>Zn(78%)>Ni(48%). The combined MBR-RO system enhanced metal removal from municipal wastewater to the levels of >90.9->99.8%, while for wastewater spiked with heavy metals the removal efficiencies were >98.4%. Fixed bed column packed with zeolite was effective for the removal of Cu, Pb and Zn from the RO concentrate, while Ni removal was satisfactory only at the initial stages of column operation. The presence of heavy metals increased inorganic fouling. (C) 2011 Elsevier B.V. All rights reserved.