Devastating vapour cloud explosions can only develop under appropriate (boundary) conditions. The record of vapour cloud explosion incidents from the past demonstrates that these conditions are-readily met by the congestion by process equipment at (petro-) chemical plant sites. Therefore, the possibility of an accidental release of a flammable and a subsequent vapour cloud explosion is a major hazardous scenario considered in any risk assessment with regard to the process industries. If an extended flammable vapour cloud at a chemical plant site extends over more than one process unit, which are separated by lanes of sufficient width, the vapour cloud explosion on ignition develops the same number of separate blasts. If, on the other hand, the separation between the units is insufficient, the vapour cloud explosion develops one big blast. The critical separation distance (SD) is the criterion that allows discriminating in this matter for blast modelling purposes. This paper summarises some major results of an experimental research programme with the objective to develop practical guidelines with regard to the critical SD. To this end, a series of small-scale explosion experiments have been performed with vapour clouds containing two separate configurations of obstacles. Blast overpressures at various stations around have been recorded while the SD between the two configurations of obstacles was varied. The experimental programme resulted in some clear indications for the extent of the critical SD between separate areas of congestion. On the basis of safety and conservatism, these indications have been rendered into a concrete guideline. Application of this guideline would allow a greater accuracy in the modelling of blast from vapour cloud explosions. (C) 2003 Elsevier Science Ltd. All rights reserved.