Reducing the unavailability of safety systems at nuclear power plants, by utilizing the probabilistic safety assessment (PSA) methodology, is one of the prime goals in the nuclear industry. In that sense, optimization of test and maintenance activities, which are defined within the technical specifications, represents quite popular and interesting domain. Obtaining optimal test and maintenance schedule is of great significance for improving system availability and performance as well as plant availability in general. On the other side, equipment aging has gradually become a major concern in the nuclear industry since the number of safety systems components, that are approaching their wear-out stage, is rising fast. Nuclear power plants life management programs, considering safety components aging, are being developed and employed. The immense uncertainty associated to the available component aging rates databases poses significant difficulties in the process of incorporation and quantification of the aging effect within the PSA and, subsequently, in the decision-making process. In this paper, an approach for optimization of surveillance test interval of standby equipment with highly uncertain aging parameters, based on genetic algorithm technique and PSA, is presented. A standard standby safety system in nuclear power plant is selected as a case study. A Monte Carlo simulation-based approach is used to assess uncertainty propagation on system level. Optimal test interval is derived on the basis of minimal system unavailability and minimal impact of components aging parameters uncertainty. The results obtained in this application indicate the fact that risk-informed surveillance requirements differ from existing ones in technical specifications as well as show the importance of considering aging data uncertainties in component aging modeling. (c) 2011 Elsevier Ltd. All rights reserved.