A novel photocatalyst iron(II) tetrahydoxymethyl-tetra(1,4-dithiin) porphyrazine (abbreviated as FePz(hmdtn)(4)) has been successfully synthesized by template method. The prepared FePz(hmdtn)(4)) was further characterized by UV-vis, FT-IR, H-1 NMR, LC-MS, XPS. FePz(hmdtn)(4) supported on an Amberlite CG-400 resin was used as a biomimetic catalyst for the activation of molecular oxygen with visible light to degrade a probe dye compound Rhodamine B (RhB) in aqueous solution with the degradation yield in 79% for 24 h. By means of cyclic voltammetry, the E-HOMO and the Delta EHOMO-LUMO were obtained by comparing the CV and DPV spectra of the metal-free compound with FePz(hmdtn)(4), which indicated the central Fe2+ showed strong electron donating property for activating molecular oxygen to degrade organic pollutants. The electrochemical results were further verified by the quantum chemical DPT calculation. (C) 2013 Elsevier B.V. All rights reserved.